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KMID : 0352119960120030313
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Journal of Kyung Hee University
1996 Volume.12 No. 3 p.313 ~ p.318
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A Comparison of Arterial Oxygenation During One-Lung Ventilation Due to Enflurane and Isoflurane Anesthesia
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Abstract
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Background:
@EN Because maintaining arterial oxygenation during one-lung ventilation (OLV) can be a clinical problem, it is useful to be aware of factors that influence arterial oxygen tension in this situation and are under the control of the
anesthesiologists.
Even though some clinical studies suggest that isoflurane provides superior PaO2 during OLV than does halothane, it is not well known which anesthetic agent is associated with higher PaO2 levels between enflurane and isoflurane.
@ES Methods:
@EN Thirty adult patients, who had planned to perform OLV anesthesia, were studied in a cross-over design. Patients were randomized into two groups. Group 1(n=15) received 1 MAC enflurane in 100% oxygen from induction until after the first 30 min
of
OLV, then were switched to 1 MAC isoflurane. In group 2, the order of the anesthetics was reversed.
@ES Results:
@EN 1) Isoflurane was associated with higher PaO2 values during OLV (p<0.05). Mean (±SD) PaO2 after 30min OLV isoflurane was 238(±124) mmHg versus 191(±105) mmHg after 30min OLV enflurane.
2) There were no significant differences between anesthetic gases in the measured hemodynamic or respiratory variables.
@ES Conclusion:
@EN During OLV, the PaO2 values with 1 MAC isoflurane were greater than those with enflurane.
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